Disease Prevention, Healthy Aging, Nature, Lifestyle, Functional foods;

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Strategies for a healthy aging: One size never fits all

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Personalised functional foods addressing your personal health needs >>>

 

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SirtFood Shot

SirtFood Shot

A DNA-based weight management and beauty shot. An outstanding combination of epigenetic active nutraceuticals that is based on science and inspired...

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SirtFood Shot

SirtFood Shot

A DNA-based weight management and beauty shot. An outstanding combination of epigenetic active nutraceuticals that is based on science and inspired...

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Gut brain Immune biotics >

Health retreat >

Functional food of the month

Caloric Restriction-, Fasting Mimetics. EGCE, Quercetin, Spermidin, Phloretin, Curcumin

Caloric restriction, fasting

 

To date, caloric restriction, fasting (i.e., a reduction in caloric intake without malnutrition) is the only  intervention that has consistently been found to extend  life span.  Importantly, only prolonged caloric restriction, fasting,  has been found to  increase ketogenic metabolites and to delay the onset of age-associated disease conditions such as cancer and diabetes.  In recent studies fasting  has been shown to improve a number of health outcomes including cardiac risk factors, improving insulin-sensitivity, and enhancing mitochondrial function,  to reduce oxidative damage to both DNA and RNA. Several biological mechanisms may account for the increase in health span and longevity such as downregulation of answers to oxidative stress, increased autophagy, senolysis, maintenance of a healthy population of mitochondria though biogenesis.

CR and Sirtuins  Guarente et al., [68] formulated the hypothesis that nutrient-sensing regulators mediate the effects of this diet on aging and diseases based on the findings that sirtuins were NAD+-dependent protein deacetylases and known to counter aging.  It is also clear that other nutrient sensors, such as AMPK, mTOR  and FOXO  are very important in linking diet, metabolism, and aging.

 

Fasting mimetics

As  fasting  is often seen as difficult, ways have been investigated to mimic fasting and caloric restriction mechanisms and their benefits. Many drugs and nutraceuticals have been studied to act as mimetics of caloric restriction, fasting which has promoted the emergence of caloric restriction fasting mimetics. Fasting mimetic compounds can be defined as compounds that mimic the protective pathways of caloric restriction and impacts the hallmarks of aging e.g autophagy and senolysis. (Fig 29). There is growing evidence that caloric restriction, fasting and fasting mimetics may trigger senolysis.

CR and fasting mimetics mimic several  molecular consequences of fasting. Main affected pathways include the SIRT, AMPK and mTOR pathway. Metformin exposure decreases mitochondrial function. AMPK inhibits glycogen synthesis, fatty acid oxidation, HMG-Co-A Reductase, and mTOR function. Decreased mTORC1 function results in increased autophagy.  Polyphenols, Spermidine, and Aspirin increase SIRT1 activity, inducing deacetylation of the RelA/p65 component and inhibit proinflammatory gene expression.  There are a number of naturally occurring polyphenols, including curcumin, resveratrol, catechins especially EGCG, gallic acid apigenin, quercetin as well as the polyamine spermidine that are discussed as CR/fasting mimetic.

 

Fasting Mimetic, Senolysis, Autophagy, Longevity

The scientific findings of health promoting activities of many fasting, CR- mimetics boosted a hype of often exaggerating health claims.  For resveratrol and green tea derived EGCG  beneficial effects on epigenetic regulation, epigenetic clock, autophagy, blocking effects on epigenetic histones of RNA, eg COVID-19  virus replication and attachment,  removal of senescent dangerous cells was reported.  Onion-Quercetin, apple-phloretin and curcumin epigenetic senolytic, antiviral and anti-inflammatory effects were seen. Spermidin became famous for its CR similar enhancement of autophagy, especially in neuro-inflammatory processes of cognitive decline. Many more bioactive plant ingredients became famous for their radicals-, ROS reducing activity.

Wheras any of these claims are based on solid scientifc  research often in vitro- or animal studies the use of many of these compounds are hampered by  often difficult extraction methods limiting necessary affordable amounts  of substances (e.g Spermidine), reduced  bioavailability or stability ( e.g. Resveratrol, EGCG ), or toxicological  aspects.  Often normal plant based nutrition provides more of these active compounds than supplements. For Spermidin see amounts per food here >>>

However, additives, supplements and function foods will be a way for personal health care for some consumers and research work from our group can be found here: >>>

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senescence, senolytics, addditives
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Startseite MY-Personal.Health

Personalised health preservation, longevity

 

We learned from modern science that our personality, what we are, comes from our inherited genes, our natural and social environment, our nutrition and the interactions between all those, our epigenetics.

Science also tells us that, when we have no problematic genetic dispositions, no stress, when we behave, move, and eat regularly according to all guidelines we stay healthy and do not need additional support for our health, e.g. no additives.

The analysis of aging and longevity showed us the different mechanisms which contribute to slow and healthy or accelerated aging. And the ageotypes of aging tell us that different personal achilles-heels of aging mechanisms drive aging personally 

As this may be often difficult we are advised to adapt the support for our health according to our personal aging-, metabolic-, lifestyle- or emotional characteristics.

Easy to obtain molecular markers from a blood drop even  allows us to detect possible ongoing dangerous molecular mechanisms of aging or aging-related complex diseases  before symptoms appear. 

At this stage personalised functional foods, which address the mechanisms can prevent  development of the disease. 

Personalised health preservation aims for a healthy aging and longevity, relies on balanced additives, nutrition and lifestyle modifications, such as ways for caloric restriction, known to prolong life.

In the area of food additives, supplements and nutraceuticals a lot of opportunistic over- promising or opportunistic  over-critical comments appear. This site reviews scientific reasonable and especially safe additives and approaches. 

Find news about products and concepts in the blogs above 

and news from conferences, talks here >>>

Science and Nature

a great team for your health

 

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If someone is looking for  health,  ask him first whether he is also prepared in the future to avoid causes of his disease – only then can you help him.    Sokrates

About Me

I always strongly believed in the interaction between nature, human engagement and culture.
Socrates and Plato believed that the Beautiful, The True and the Good should not be separated. This should be the base for our mental and physical health:

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After my studies in microbiology and genetics, medicine and environmental health I worked for more than 30 years in research in different universities in USA and Asia, at WHO in Genève and in governmental agencies and the pharmaceutical industry. I enjoyed to be consultant for OECD, EC and EPA.
Research areas were immune responses, microbiota, epigenetics, molecular and biological nutrition as well as environmental aspects. Recent projects cover individualized preventive health care, environmental health, pro- and prebiotics, epigenetic active phytoceuticals, aging and epigenetics and DNA stability in metabolic and aging related diseases.

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