Novel communication between intestinal microbes and developing immune cells in the thymus: Regulation of thymic immune development by intestinal microbes in early life
Researchers discover microbes regulate the development of specialized immune cells in the thymus that play a critical role in mucosal tolerance. Quelle: Novel communication between intestinal microbes and developing immune cells in the thymus: Regulation of thymic...
New test detects coronavirus in just 5 minutes
CRISPR-based approach is much faster than current diagnostics, but does have some limitations Quelle: New test detects coronavirus in just 5 minutes
First Regulatory Approval Granted for Oral Antiviral Favipiravir for Treatment of COVID-19 Patients Gained by Glenmark
A fast-tracked manufacturing and marketing approval for Favipiravir was granted to Glenmark Pharmaceuticals by the Drug Controller General of India (DCGI) for restricted emergency use in mild to moderate cases of COVID-19. With this approval,...
Gut microbiota and statins – biocrates life sciences ag
Impact of the gut microbiota on atorvastatin mediated effects on blood lipidsThe composition of our individual gut microbiota contributes to the digestion and absorption of nutrients from food. Similarly, orally administered medications experience the same digestive...
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission – The Lancet
The number of older people, including those living with dementia, is rising, as younger age mortality declines. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health care, and...
Epigenetic changes in the brain drive late-onset Alzheimer’s disease
New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain. Results were published today in Nature Genetics. Quelle: Epigenetic changes in the brain drive late-onset...
Auto-antibodies against type I IFNs in patients with life-threatening COVID-19 | Science
Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both...
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science
Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN)...
A Renaissance of Genomics and Drugs Is Extending Human Longevity
The causes of aging are extremely complex and unclear. But with longevity clinical trials increasing, more answers—and questions—are emerging than ever before. With the dramatic demonetization of genome reading and editing over the past decade, and Big Pharma,...
Metformin treatment linked to slowed cognitive decline
Metformin is the first-line treatment for most cases of type 2 diabetes and one of the most commonly prescribed medications worldwide, with millions of individuals using it to optimize their blood glucose levels. A new research study, conducted over six years in the...
