Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods | Microbial Cell Factories | Full Text
Paraprobiotics and postbiotics are the emerging concepts in the functional foods field because they impart an array of health-promoting properties. Although, these terms are not well defined, however, for time being these terms have been defined as here. The...
Lifelong restriction of dietary branched-chain amino acids has benefits for frailty and life span in mice | Nature Aging
Protein-restricted diets promote health and longevity in many species. While the precise components of a protein-restricted diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of protein...
Could Differences in Microbiota Explain Variability in SARS-CoV-2 Susceptibility? – Behind the Bench
There is growing evidence that the respiratory tract and gut microbiotas can help regulate the body’s response to invading respiratory viruses, while in a similar fashion, invading respiratory viruses can induce immune responses that alter the composition of the...
Chinese scientists develop gene therapy which could delay ageing | Reuters
The team of biologists from different CAS departments used the CRISPR/Cas9 method to screen thousands of genes for those which were particularly strong drivers of cellular senescence, the term used to describe cellular ageing.They identified 100 genes out of around...
Myeloid immune cells in the blood tied to severe COVID-19
Individual variations in how the immune system responds to SARS-CoV-2 appear to impact the severity of disease. Researchers at Karolinska Institutet in Sweden have now been able to show that patients with severe COVID-19 have significantly elevated levels of a certain...
Variant might partially evade protection from vaccines or prior infection, early research suggests – CNN
A new study suggests someone might be able to get infected with one of the new variants of the coronavirus even if they've had Covid-19 before or have been vaccinated.The variant was first spotted in South Africa in October and has now been found in more than a dozen...
Linoleic acid binds SARS-CoV-2 spike protein
Now, a team of researchers at the Max Planck-Bristol Center for Minimal Biology and Bristol's School of Biochemistry has identified a druggable pocket in the virus's spike protein that can be used to prevent the infection of cells. The study findings, published in the...
Metformin use reduces risk of death for patients with COVID-19 and diabetes
Use of the diabetes drug metformin—before a diagnosis of COVID-19—is associated with a threefold decrease in mortality in COVID-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham. Diabetes is a...
After dosing mix-up, latest COVID-19 vaccine success comes with big question mark | Science | AAAS
AstraZeneca and Oxford reported on 22 November in separate press releases that an interim analysis of trials in the United Kingdom and Brazil found an “average efficacy” of 70%. Both studies gave volunteers a “prime” first dose and a booster shot at least 1 month...
Researchers identify promising new compounds to potentially treat novel coronaviruses
"We determined that disrupting the SKI complex keeps the virus from copying itself, which essentially destroys it," said study corresponding author Matthew Frieman, Ph.D., Associate Professor of Microbiology and Immunology at the UMSOM. "We also identified compounds...